Endocrine Abstracts

Both type 1 and type 2 diabetes are associated with accelerated atherosclerosis. Multiple mechanisms contribute to the atherosclerotic process; however, inflammation and oxidative stress are underlying common factors. In genetically-prone atherosclerotic mouse models, inhibition of macrophage inflammatory capacity and oxidative stress substantially attenuate atherosclerosis extent and complexity. These approaches also attenuate the adipocyte response to high fat diet and adoip...